Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles,
which are widely explored and utilized by the pharmaceutical industry for drug discovery …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised
version of the gold-standard reference on the use of drug therapy in all major veterinary …

Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are
sympathetic nerves peripherally and noradrenergic brainstem nuclei A1–A7 centrally …

Introduction and objectives: The opioid overdose epidemic is exacerbated by the
emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can …

Given the brain's uniquely high cell density and tissue oxygen levels bordering on hypoxia,
the ability to rapidly and precisely match blood flow to constantly changing patterns in neural …

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …

Prevention of epileptogenesis is an unmet need in medicine. During the last 3 years,
however, several preclinical studies have demonstrated remarkable favorable effects of …

Xylazine, a veterinary tranquillizer known by drug users as “Tranq”, is being increasingly
detected in people who overdose on opioid drugs, indicating enhanced health risk of …

Rationale Deficient response inhibition is a prominent feature of many pathological
conditions characterised by impulsive and compulsive behaviour. Clinically effective doses …