Connectomics and the neural basis of behaviour

DS Galili, GSXE Jefferis, M Costa - Current opinion in insect science, 2022 - Elsevier
Highlights•Technical advances are producing bigger and denser Drosophila melanogaster
connectomes.•Mapping connectomics to other data types is a challenging but crucial …

A connectome and analysis of the adult Drosophila central brain

LK Scheffer, CS Xu, M Januszewski, Z Lu, S Takemura… - elife, 2020 - elifesciences.org
The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

[HTML][HTML] A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

BK Hulse, H Haberkern, R Franconville… - Elife, 2021 - elifesciences.org
Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

The connectome of the adult Drosophila mushroom body provides insights into function

F Li, JW Lindsey, EC Marin, N Otto, M Dreher… - Elife, 2020 - elifesciences.org
Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

The Drosophila Split Gal4 System for Neural Circuit Mapping

H Luan, F Diao, RL Scott, BH White - Frontiers in neural circuits, 2020 - frontiersin.org
The diversity and dense interconnectivity of cells in the nervous system present a huge
challenge to understanding how brains work. Recent progress toward such understanding …

Connectomic reconstruction of a female Drosophila ventral nerve cord

A Azevedo, E Lesser, JS Phelps, B Mark, L Elabbady… - Nature, 2024 - nature.com
A deep understanding of how the brain controls behaviour requires mapping neural circuits
down to the muscles that they control. Here, we apply automated tools to segment neurons …

A Connectome of the Adult Drosophila Central Brain

CS Xu, M Januszewski, Z Lu, S Takemura… - BioRxiv, 2020 - biorxiv.org
The neural circuits responsible for behavior remain largely unknown. Previous efforts have
reconstructed the complete circuits of small animals, with hundreds of neurons, and selected …

Information flow, cell types and stereotypy in a full olfactory connectome

P Schlegel, AS Bates, T Stürner, SR Jagannathan… - Elife, 2021 - elifesciences.org
The hemibrain connectome provides large-scale connectivity and morphology information
for the majority of the central brain of Drosophila melanogaster. Using this data set, we …

Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development

YCD Chen, YC Chen, R Rajesh… - Proceedings of the …, 2023 - National Acad Sciences
Cell-type-specific tools facilitate the identification and functional characterization of the
distinct cell types that form the complexity of neuronal circuits. A large collection of existing …

Neural circuitry linking mating and egg laying in Drosophila females

F Wang, K Wang, N Forknall, C Patrick, T Yang… - Nature, 2020 - nature.com
Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous
females. Oviposition is typically rare in virgin females but is initiated after copulation. Here …