Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …

Optical manipulations of genetically defined cell types have generated significant insights
into the dynamics of neural circuits. While optogenetic activation has been relatively …

Optical control of G protein-coupled receptor (GPCR) signaling is a highly valuable
approach for comprehensive understanding of GPCR-based physiologies and controlling …

Phototransduction is based on opsins that drive distinct types of Gα cascades. Although
nonvisual photosensitivity has long been known in marine bivalves, the underlying …

Animal opsins, light-sensitive G protein-coupled receptors, have been used for optogenetic
tools to control G protein-dependent signaling pathways. Upon G protein activation, the Gα …

During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect
chemoattractant gradients. The downstream signaling system is wired with multiple …

Optogenetics uses light‐sensitive proteins, so‐called optogenetic tools, for highly precise
spatiotemporal control of cellular states and signals. The major limitations of such tools …

There is no consensus on the best inhibitory optogenetic tool. Since Gi/o signalling is a
native mechanism of neuronal inhibition, we asked whether Lamprey Parapinopsin …

Animals detect light using opsin photopigments. Xenopsin, a recently classified subtype of
opsin, challenges our views on opsin and photoreceptor evolution. Originally thought to …