Macropinocytosis represents a distinct pathway of endocytosis in mammalian cells. This
actin‐driven endocytic process is not directly co‐ordinated by the presence of cargo but can …

▪ Abstract Phagocytosis and phagolysosome biogenesis represent fundamental biological
processes essential for proper tissue homeostasis, development, elimination of invading …

The tubercle bacillus parasitizes macrophages by inhibiting phagosome maturation into the
phagolysosome. This phenomenon underlies the tuberculosis pandemic involving 2 billion …

Mycobacterium tuberculosis (Mtb) parasitizes host macrophages and subverts host innate
and adaptive immunity. Several cytokines elicited by Mtb are mediators of mycobacterial …

The capacity of Mycobacterium tuberculosis to infect latently over one billion people and
cause two million fatalities annually rests with its ability to block phagosomal maturation into …

Mycobacterium tuberculosis is successful as a pathogen because of its ability to persist in an
immunocompetent host. This bacterium lives within the macrophage, a cell whose function is …

The persistence of tuberculosis within pulmonary granulomatous lesions is a complex
phenomenon, with bacterial survival occurring in a focal region of high immune activity. In …

Legionella pneumophila establishes a replication vacuole within phagocytes that requires
the bacterial Dot/Icm apparatus for its formation. This apparatus is predicted to translocate …

One-third of the world's population is infected with Mycobacterium tuberculosis (Mtb), and
three million people die of tuberculosis each year. Following its ingestion by macrophages …

Mycobacteria activate a series of macrophage signalling pathways upon engaging host cell
receptors and during the invasion process. These signals initiate a cascade of events …