One of the key features of the immune system is its extraordinary capacity to discriminate
between self and non-self and to respond accordingly. Several molecular interactions allow …

Sialic acid sugars are vital regulators of the immune system through binding to
immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on …

The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …

Sialic acids constitute a family of negatively charged structurally diverse monosaccharides
that are commonly presented on the termini of glycans in higher animals and some …

The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of
immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs …

The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are
recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical …

The Siglec family of cell surface receptors have emerged as attractive targets for cell-
directed therapies due to their restricted expression on immune cells, endocytic properties …

CD22 and Siglec-G are two B-cell expressed members of the Siglec (sialic acid-binding
immunoglobulin (Ig)-like lectin) family and are potent inhibitors of B-cell signaling. Genetic …

Sialic acid sugars that terminate cell‐surface glycans form the ligands for the sialic acid
binding immunoglobulin‐like lectin (Siglec) family, which are immunomodulatory receptors …

Carbohydrate‐binding proteins are generally characterized by poor affinities for their natural
glycan ligands, predominantly due to the shallow and solvent‐exposed binding sites. To …