Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque

A Janoudi, FE Shamoun, JK Kalavakunta… - European heart …, 2016 - academic.oup.com
Evolution of plaque that is prone to rupture is characterized by inflammation and physical
changes. Accumulation of low-density lipoprotein in the sub-intima provides esterified …

Examining atherosclerotic lesions in three dimensions at the nanometer scale with cryo-FIB-SEM

J Capua-Shenkar, N Varsano… - Proceedings of the …, 2022 - National Acad Sciences
We employed in a correlative manner an unconventional combination of methods,
comprising cathodoluminescence, cryo–scanning electron microscopy (SEM), and cryo …

Cholesterol crystals and atherosclerosis

Y Baumer, NN Mehta, AK Dey, TM Powell-Wiley… - 2020 - academic.oup.com
Cholesterol crystals and atherosclerosis | European Heart Journal | Oxford Academic Skip to
Main Content Advertisement intended for healthcare professionals Oxford Academic Journals …

Frequency of cholesterol crystals in culprit coronary artery aspirate during acute myocardial infarction and their relation to inflammation and myocardial injury

GS Abela, JK Kalavakunta, A Janoudi, D Leffler… - The American journal of …, 2017 - Elsevier
Cholesterol crystals (CCs) have been associated with plaque rupture through mechanical
injury and inflammation. This study evaluated the presence of CCs during acute myocardial …

[HTML][HTML] Effect of aspirin on cholesterol crystallization: a potential mechanism for plaque stabilization

L Fry, A Lee, S Khan, K Aziz, A Vedre… - American Heart Journal …, 2022 - Elsevier
Background and aims Cholesterol crystals (CCs) have been found to be critical in the
evolution and progression of atherosclerotic plaque leading up to rupture. This includes …

[HTML][HTML] Cholesterol crystals induce coagulation activation through complement-dependent expression of monocytic tissue factor

CS Gravastrand, B Steinkjer, B Halvorsen… - The Journal of …, 2019 - journals.aai.org
Cholesterol crystals (CC) are strong activators of complement and could potentially be
involved in thromboinflammation through complement–coagulation cross-talk. To explore …

Viewing atherosclerosis through a crystal lens: how the evolving structure of cholesterol crystals in atherosclerotic plaque alters its stability

SM Nidorf, A Fiolet, GS Abela - Journal of Clinical Lipidology, 2020 - Elsevier
Reducing the residual risk of cardiovascular (CV) events in patients with atherosclerosis
continues to be a challenge. Thus, understanding how cholesterol spontaneously self …

[HTML][HTML] Cholesterol crystal embolization following plaque rupture: a systemic disease with unusual features

F Ghanem, D Vodnala, JK Kalavakunta… - Journal of biomedical …, 2017 - ncbi.nlm.nih.gov
Cholesterol crystal embolic (CCE) syndrome is often a clinically challenging condition that
has a poor prognostic implication. It is a result of plaque rupture with release of cholesterol …

Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies

GB Silva, LM Gierman, JJ Rakner, GS Stødle… - Frontiers in …, 2020 - frontiersin.org
Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with
cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can …