Early-life experience, epigenetics, and the developing brain

M Kundakovic, FA Champagne - Neuropsychopharmacology, 2015 - nature.com
Abstract Development is a dynamic process that involves interplay between genes and the
environment. In mammals, the quality of the postnatal environment is shaped by parent …

Naturalistic rodent models of chronic early‐life stress

J Molet, PM Maras, S Avishai‐Eliner… - Developmental …, 2014 - Wiley Online Library
ABSTRACT A close association between early‐life experience and cognitive and emotional
outcomes is found in humans. In experimental models, early‐life experience can directly …

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

SM O'Mahony, G Clarke, TG Dinan, JF Cryan - Neuroscience, 2017 - Elsevier
The prenatal and postnatal early-life periods are both dynamic and vulnerable windows for
brain development. During these important neurodevelopmental phases, essential …

Neurobiology of resilience in depression: immune and vascular insights from human and animal studies

KA Dudek, L Dion‐Albert, FN Kaufmann… - European Journal of …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a chronic and recurrent psychiatric condition
characterized by depressed mood, social isolation and anhedonia. It will affect 20% of …

Epigenetic mechanisms mediating the long-term effects of maternal care on development

FA Champagne, JP Curley - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
The long-term consequences of early environmental experiences for development have
been explored extensively in animal models to better understand the mechanisms mediating …

Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions …

CA Oomen, H Soeters, N Audureau… - Journal of …, 2010 - Soc Neuroscience
Early life stress increases the risk for developing stress-related pathologies later in life.
Recent studies in rats suggest that mild early life stress, rather than being overall …

Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms

CR Pryce, J Feldon - Neuroscience & Biobehavioral Reviews, 2003 - Elsevier
The major characteristics of the postnatal environment of the rat pup are its mother and
littermates. The pup, which is poorly developed at birth, matures rapidly in this environment …

Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?

J Lehmann, J Feldon - Reviews in the Neurosciences, 2000 - degruyter.com
Over the last decades of research there has been increasing interest in endocrine and
behavioral effects of postnatal environmental manipulations. A manipulation procedure that …

Early life stress in rodents: animal models of illness or resilience?

S Murthy, E Gould - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
Early life adversity is a known risk factor for mood and anxiety disorders in adult humans
(Heim et al., 2010; Huh et al., 2014; Rehan et al., 2017). Given the prevalence of both …

Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty.

FA Champagne, MJ Meaney - Behavioral neuroscience, 2007 - psycnet.apa.org
Abstract [Correction Notice: An erratum for this article was reported in Vol 122 (2) of
Behavioral Neuroscience (see record 2008-03769-025). Figure 1 on Page 1356 was …