Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Cancer is the leading cause of deaths worldwide, though significant advances have
occurred in its diagnosis and treatment. The development of resistance against …

Micromonospora, one of the most important actinomycetes genera, is well-known as the
treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth …

Colorectal cancer (CRC) is a common, and deadly disease. Despite the improved
knowledge on CRC heterogeneity and advances in the medical sciences, there is still an …

This review covers the development of the genus Micromonospora as a model for natural
product research and the timeline of discovery progress from the classical bioassay-guided …

Analysis of the genome sequence of Streptomyces sp. KCB13F003 showed the presence of
a cryptic gene cluster encoding flavin-dependent halogenase and nonribosomal peptide …

After the successful discoveries of numerous antibiotics from microorganisms, frequent
reisolation of known compounds becomes an obstacle in further development of new drugs …

We report a concise asymmetric synthesis of rakicidin A, a macrocyclic depsipeptide that
selectively inhibits the growth of hypoxic cancer cells and stem‐like leukemia cells. Key …

The emergence of a large number of antimicrobialresistant organisms is a cause for
concern. Nature is historically the source of drugs; indeed a considerable number of drugs …