Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-
growing technique for visualization of the spatial distribution of the small molecular and …

Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

Direct visualization of metabolic dynamics in living animals with high spatial and temporal
resolution is essential to understanding many biological processes. Here we introduce a …

Mass spectrometry imaging (MSI) based on matrix-assisted laser desorption ionization
(MALDI) is widely used in proteomics. However, matrix-free technologies are gaining …

Small molecule neurotransmitters are essential for the function of the nervous system, and
neurotransmitter imbalances are often connected to neurological disorders. The ability to …

Introduction Diabetic kidney disease (DKD) is the most prevalent complication in diabetic
patients, which contributes to high morbidity and mortality. Urine and plasma metabolomics …

High-throughput screening technologies are widely used for elucidating biological activities.
These typically require trade-offs in assay specificity and sensitivity to achieve higher …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is
routinely used to determine the spatial distributions of various biomolecules in tissues …

Mass spectrometry imaging (MSI) of neurotransmitters has so far been mainly performed by
matrix-assisted laser desorption/ionization (MALDI) where derivatization reagents …