Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

Cubosomes as an emerging platform for drug delivery: A review of the state of the art

MAS Abourehab, MJ Ansari, A Singh… - Journal of Materials …, 2022 - pubs.rsc.org
Lipid-based drug-delivery nanoparticles, including non-lamellar-type, mesophasic
nanostructured materials of lyotropic liquid crystals (LLCs), have been a topic of interest for …

Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity

S Ahmed, MM Farag, MA Sadek… - Journal of Liposome …, 2024 - Taylor & Francis
This study aimed to formulate diacerein loaded terpene-enriched invasomes (DCN-TINV) to
fulfill a fruitful management of osteoarthritis. A 23 factorial design was adopted, including A …

Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo …

S Ahmed, MM Amin, SM El-Korany, S Sayed - Drug Delivery, 2022 - Taylor & Francis
The purpose of this manuscript was to develop and optimize Fenticonazole Nitrate (FTN)-
loaded novasomes aiming to enhance drug corneal penetration and to improve its …

Fabrication of betaxolol hydrochloride-loaded highly permeable ocular bilosomes (HPOBs) to combat glaucoma: In vitro, ex vivo & in vivo characterizations

MG Sakr, SA El-Zahaby, AM Al-Mahallawi… - Journal of Drug Delivery …, 2023 - Elsevier
Betaxolol hydrochloride is a water-soluble antiglaucoma drug suffering from poor ocular
bioavailability necessitating frequent dosing that impede patient adherence to treatment …

Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation

NA Shoman, RM Gebreel, MA El-Nabarawi, A Attia - Drug Delivery, 2023 - Taylor & Francis
To design and evaluate hyaluronan-based cubosomes loaded with bromfenac sodium (BS)
for ocular application to enhance the corneal permeation and retention in pterygium and …

Lipid-based nanocarriers for ocular drug delivery: An updated review

B Das, AK Nayak, S Mallick - Journal of Drug Delivery Science and …, 2022 - Elsevier
Recent years have witnessed a boom in ocular nanomedicine research with a number of
lipid-based nanocarriers such as liposomes, niosomes, cubosomes, nanoemulsions, solid …

Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems

JSL Leu, JJX Teoh, ALQ Ling, J Chong, YS Loo… - Pharmaceutics, 2023 - mdpi.com
Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline
nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug …

Progress and challenges of lyotropic liquid crystalline nanoparticles for innovative therapies

AVP Silvestrini, BW Debiasi, FG Praça… - International Journal of …, 2022 - Elsevier
Since the late 20th century, we have witnessed a growing and substantial advance in
nanomedicine, in part due to the development of multifunctional and multimodal …

Novel crosslinked nanoparticles of chitosan oligosaccharide and dextran sulfate for ocular administration of dorzolamide against glaucoma

SR Pardeshi, MP More, CV Pardeshi… - Journal of Drug Delivery …, 2023 - Elsevier
Glaucoma is related to the damaged optic nerve leading to the development of high
intraocular pressure. Currently, 12 million people in India suffer from glaucoma, making it the …