During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antiviral agents
(DAA) is associated with high rates of sustained virologic response. Remaining factors …

The advent of direct-acting antivirals (DAAs) has brought about a sudden renaissance in the
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …

Drug resistance is prevalent across many diseases, rendering therapies ineffective with
severe financial and health consequences. Rather than accepting resistance after the fact …

Hepatitis C virus (HCV) infection has become a global health problem with enormous risks.
Nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) is a component …

Introduction: Chronic hepatitis C virus (HCV) infection has become a curable disease.
Sustained virologic response rates above 90% have been achieved with recommended …

Multiple direct-acting antiviral (DAA)-based regimens are currently approved that provide
one or more interferon-free treatment options for hepatitis C virus (HCV) genotypes (G) 1–6 …

There is no comprehensive study available on the natural hepatitis C virus (HCV)
polymorphism in sites associated with resistance including all viral genotypes which may …

Introduction: The treatment of hepatitis C virus (HCV) infection has dramatically improved in
recent years with the widespread use of interferon-free combination regimens. Despite the …

Inhibition of the viral RNA-dependent RNA polymerase (RdRp) to resolve chronic infection is
a useful therapeutic strategy against Hepatitis C virus (HCV). Non-nucleoside inhibitors …