Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐
inflammatory senescence‐associated secretory phenotype (SASP), which is a major …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …

Senescent cells, formed in response to physiological and oncogenic stresses, facilitate
protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells …

Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …