Immune checkpoint inhibitor–related dermatologic adverse events

AN Geisler, GS Phillips, DM Barrios, J Wu… - Journal of the American …, 2020 - Elsevier
Immune checkpoint inhibitors have emerged as a pillar in the management of advanced
malignancies. However, nonspecific immune activation may lead to immune-related adverse …

Dermatologic reactions to immune checkpoint inhibitors: skin toxicities and immunotherapy

V Sibaud - American journal of clinical dermatology, 2018 - Springer
The development of immune checkpoint inhibitors [monoclonal antibodies targeting
cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein 1 (PD …

Cutaneous immune-related adverse events (irAEs) to immune checkpoint inhibitors: a dermatology perspective on management

A Muntyanu, E Netchiporouk… - Journal of …, 2021 - journals.sagepub.com
Immune checkpoint inhibitors have proven to be efficacious for a broad spectrum of solid
organ malignancies. These monoclonal antibodies lead to cytotoxic T-cell activation and …

Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies

V Sibaud, N Meyer, L Lamant, E Vigarios… - Current opinion in …, 2016 - journals.lww.com
Dermatologic complications of anti-PD-1/PD-L1 immune checkpo... : Current Opinion in
Oncology Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies …

Diverse types of dermatologic toxicities from immune checkpoint blockade therapy

JL Curry, MT Tetzlaff, P Nagarajan… - Journal of cutaneous …, 2017 - Wiley Online Library
Immunomodulatory drugs that leverages host immune mechanisms to destroy tumor cells
have been met with great promise in the treatment of cancer. Immunotherapy, targeting …

Immune checkpoint inhibitors unleash pathogenic immune responses against the microbiota

ZI Hu, VM Link, DS Lima-Junior… - Proceedings of the …, 2022 - National Acad Sciences
Immune checkpoint inhibitors (ICIs) are essential components of the cancer therapeutic
armamentarium. While ICIs have demonstrated remarkable clinical responses, they can be …

Dermatologic toxicities to immune checkpoint inhibitor therapy: A review of histopathologic features

SR Ellis, AT Vierra, JW Millsop, ME Lacouture… - Journal of the American …, 2020 - Elsevier
Antineoplastic agents that use the immune system have revolutionized cancer treatment.
Specifically, implementation of immune checkpoint inhibitors, monoclonal antibodies that …

Epidermal programmed cell death‐ligand 1 expression in TEN associated with nivolumab therapy

KL Vivar, M Deschaine, J Messina… - Journal of cutaneous …, 2017 - Wiley Online Library
Nivolumab is a programmed cell death receptor‐1 (PD‐1) antibody used in the treatment of
metastatic or unresectable melanoma. Cutaneous reactions are the most common adverse …

Lichenoid dermatologic toxicity from immune checkpoint blockade therapy: a detailed examination of the clinicopathologic features

MT Tetzlaff, P Nagarajan, S Chon, A Huen… - The American Journal …, 2017 - journals.lww.com
Immunotherapy targeting the programmed cell death 1 (PD-1) receptor has demonstrated
tremendous promise in the treatment of advanced solid tumors. Dermatologic toxicities …

Management of cutaneous immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors: a systematic review

ER Nadelmann, JE Yeh, ST Chen - JAMA oncology, 2022 - jamanetwork.com
Importance There exists a paucity of literature that summarizes the effective management of
cutaneous immune-related adverse events (cirAEs) in patients with cancer who are …