Strategies for immunotherapy of cancer

The prevailing mood among immunologists and oncologists concerning immunotherapy of
cancer is still one of gloom. Indeed, as of this writing, the impact of immunotherapy on …

[HTML][HTML] Adoptive immunotherapy for posttransplantation viral infections

CM Bollard, I Kuehnle, A Leen, CM Rooney… - Biology of Blood and …, 2004 - Elsevier
Viral diseases are a major cause of morbidity and mortality after hemopoietic stem cell
transplantation. Because viral complications in these patients are clearly associated with the …

Cytotoxic T Lymphocyte Therapy for Epstein-Barr Virus+ Hodgkin's Disease

CM Bollard, L Aguilar, KC Straathof, B Gahn… - The Journal of …, 2004 - rupress.org
Epstein Barr virus (EBV)+ Hodgkin's disease (HD) expresses clearly identified tumor
antigens derived from the virus and could, in principle, be a target for adoptive …

Treatment of Epstein-Barr-virus-positive post-transplantation lymphoproliferative disease with partly HLA-matched allogeneic cytotoxic T cells

T Haque, GM Wilkie, C Taylor, PL Amlot, P Murad… - The Lancet, 2002 - thelancet.com
Summary Background Epstein-Barr virus (EBV)-associated posttransplantation
lymphoproliferative disease (PTLD) is a common, often fatal, complication of bone-marrow …

Infusion of autologous Epstein-Barr virus (EBV)–specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients …

P Comoli, M Labirio, S Basso, F Baldanti… - Blood, The Journal …, 2002 - ashpublications.org
Epstein-Barr virus (EBV)–associated posttransplantation lymphoproliferative disorders
(PTLDs) are a well-recognized complication of immunosuppression in solid organ transplant …

Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells

JB Latouche, M Sadelain - Nature biotechnology, 2000 - nature.com
The adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) is a promising
therapeutic approach for a number of diseases. To overcome the difficulty in generating …

Cytolytic CD4+-T-Cell Clones Reactive to EBNA1 Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation

S Nikiforow, K Bottomly, G Miller, C Münz - Journal of virology, 2003 - Am Soc Microbiol
In the absence of immune surveillance, Epstein-Barr virus (EBV)-infected B cells generate
neoplasms in vivo and transformed cell lines in vitro. In an in vitro system which modeled the …

Monitoring four herpesviruses in unrelated cord blood transplantation

N Tanaka, H Kimura, Y Hoshino, K Kato… - Bone marrow …, 2000 - nature.com
Cord blood transplantation, which has lower risk of graft-versus-host disease than bone
marrow transplantation, might have higher risk of infections. A system to quantify four …

Quantitation, selection, and functional characterization of Epstein-Barr virus–specific and alloreactive T cells detected by intracellular interferon-γ production and …

G Koehne, KM Smith, TL Ferguson… - Blood, The Journal …, 2002 - ashpublications.org
Techniques for the quantitation of virus-specific and alloantigen-reactive T cells vary in their
measurement of clinically relevant T-cell effector populations, their sensitivity and …

Treatment of Epstein-Barr virus-associated malignancies with specific T cells

S Gottschalk, HE Heslop, CM Rooney - 2002 - Elsevier
Abstract Latent Epstein-Barr virus (EBV) infection is associated with a heterogeneous group
of malignancies, including Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal …