Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya, A Vezzani… - Pharmacological …, 2020 - Elsevier
Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Neuroinflammation and proinflammatory cytokines in epileptogenesis

A Soltani Khaboushan, N Yazdanpanah… - Molecular neurobiology, 2022 - Springer
Increasing evidence corroborates the fundamental role of neuroinflammation in the
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the …

International consensus recommendations for management of new onset refractory status epilepticus including febrile infection‐related epilepsy syndrome …

R Wickstrom, O Taraschenko, R Dilena, ET Payne… - …, 2022 - Wiley Online Library
Objective This study was undertaken to develop consensus‐based recommendations for the
management of adult and pediatric patients with new onset refractory status epilepticus …

Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier

J Li, M Zheng, O Shimoni, WA Banks, AI Bush… - Advanced …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Ketogenic diet and neuroinflammation

S Koh, N Dupuis, S Auvin - Epilepsy Research, 2020 - Elsevier
The high-fat, low-carbohydrate ketogenic diet (KD) is an established treatment for drug-
resistant epilepsy with a proven efficacy. The KD is being explored for Febrile Infection …

Inflammation and reactive oxygen species as disease modifiers in epilepsy

G Terrone, S Balosso, A Pauletti, T Ravizza… - …, 2020 - Elsevier
Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …

The interconnected mechanisms of oxidative stress and neuroinflammation in epilepsy

ALM Parsons, EMV Bucknor, E Castroflorio, TR Soares… - Antioxidants, 2022 - mdpi.com
One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

Anakinra usage in febrile infection related epilepsy syndrome: an international cohort

YC Lai, E Muscal, E Wells, N Shukla… - Annals of clinical …, 2020 - Wiley Online Library
Febrile‐infection related epilepsy syndrome (FIRES) is a devastating neurological condition
characterized by a febrile illness preceding new onset refractory status epilepticus (NORSE) …