JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

Angiogenesis is the development of new blood vessels, which is required for tumor growth
and metastasis. Signal transducer and activator of transcription factor 3 (STAT3) is a …

Cancer metastasis is the main cause of death in breast cancer (BC) patients. Therefore,
prediction and treatment of metastasis is critical for enhancing the survival of BC patients. In …

Epigenetic modifications affect the differentiation of T cell subsets and the pathogenesis of
autoimmune diseases, but many mechanisms of epigenetic regulation of T cell …

Abstract Background Circular RNAs (circRNAs) are a new class of noncoding RNAs that
have gained increased attention in human tumor research. However, the identification and …

It is the intention of this review to characterize milk's role as an epigenetic regulator in health
and disease. Based on translational research, we identify milk as a major epigenetic …

Increased expression of vascular cell adhesion molecule (VCAM)-1 on the activated arterial
endothelial cell (EC) surface critically contributes to atherosclerosis which may in part be …

Epigenetic alterations such as DNA methylation, histone acetylation, and chromatin
remodeling can control gene expression by regulating gene transcription. DNA methylation …

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the human
stomach leading to the development of chronic gastritis, peptic ulcers and gastric …

Major tumor suppressor and transcription factor p53 coordinates expression of many genes
hence affecting critical cellular functions including cell cycle, senescence, and apoptosis …