Postoperative cognitive dysfunction is receiving increasing attention, particularly as it mainly
affects the (growing) elderly population. Until recently, cognitive deficits after cardiac surgery …

Opioid-free anesthesia (OFA) is emerging as a new stimulating research perspective. The
rationale to propose OFA is based on the aim to avoid the negative impact of intraoperative …

A common histological artifact of brain is the presence of contracted, intensely stained
neurons. Such cells are termed dark neurons, and can be produced by post-mortem …

Background Postoperative cognitive dysfunction (POCD) after coronary artery bypass graft
surgery is a common complication for which, despite many clinical investigations, no …

STUDY OBJECTIVE: To evaluate the capacity of dexmedetomidine (DEX), an α2 adrenergic
agonist drug, as a substitute for remifentanil (REM), a potent opioid, in total intravenous …

Vagal nerve stimulation is an important adjunctive therapy for medically refractory epilepsy
and major depression. Additionally, it may prove effective in treating obesity, Alzheimer's …

Background and aim: Remifentanil is an ultra‐short‐acting opioid, increasingly used today
in neuroanesthesia and neurointensive care. Its characteristics make remifentanil a …

The primary concerns for providing anesthesia to the patient with epilepsy are the capacity
of anesthetics to modulate or potentiate seizure activity and the interaction of anesthetic …

Recent advances in the management of peri-operative pain principally concern the
recognition of the risk of developing pain chronicity. The best identified risk factors for pain …

Opiate drug abuse, through selective actions at μ opioid receptors (MOR), exacerbates the
pathogenesis of human immunodeficiency virus-1 (HIV-1) in the CNS by disrupting glial …