Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Iron in neurodegeneration–cause or consequence?

A Ndayisaba, C Kaindlstorfer… - Frontiers in neuroscience, 2019 - frontiersin.org
Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Oxidative stress and the pathogenesis of Alzheimer′ s disease

Y Zhao, B Zhao - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …

[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives

KD Fasae, AO Abolaji, TR Faloye, AY Odunsi… - Journal of Trace …, 2021 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)

FX Theillet, A Binolfi, T Frembgen-Kesner… - Chemical …, 2014 - ACS Publications
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

The adverse effects of air pollution on the nervous system

S Genc, Z Zadeoglulari, SH Fuss… - Journal of toxicology, 2012 - Wiley Online Library
Exposure to ambient air pollution is a serious and common public health concern associated
with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air …

Fluorescence imaging of metal ions implicated in diseases

X Qian, Z Xu - Chemical Society Reviews, 2015 - pubs.rsc.org
Metal ions play an important role in various biological processes, their abnormal
homeostasis in cells is related to many diseases, such as neurodegenerative disease …

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

H Kozlowski, M Luczkowski, M Remelli… - Coordination Chemistry …, 2012 - Elsevier
The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Carbon nanodots prepared from o-phenylenediamine for sensing of Cu 2+ ions in cells

M Vedamalai, AP Periasamy, CW Wang, YT Tseng… - Nanoscale, 2014 - pubs.rsc.org
A simple hydrothermal method was applied to prepare carbon nanodots (C dots) from o-
phenylenediamine (OPD). The C dots exhibit photoluminescence at 567 nm when excited at …