Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They
not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate …

Ovarian cancer (OC) has a high impact on morbidity and mortality in the female population.
Survival is modest after platinum progression. Therefore, the search for new therapeutic …

Poly (ADP) ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous
recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment …

Poly (ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-
translationally modify proteins through poly (ADP-ribosyl) ation (PARylation)—the transfer of …

Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is
associated with multiple disease processes such as infections and chronic inflammatory …

Background Type 2 diabetes mellitus (T2DM) is characterized by disrupted glucose
homeostasis and metabolic abnormalities, with oxidative stress and inflammation playing …

Heat shock protein (HSP) 40 has emerged as a key factor in both innate and adaptive
immunity, whereas the role of HLJ1, a molecular chaperone in HSP40 family, in modulating …

Simple Summary Members of the poly (ADP-ribose)-polymerase (PARP) enzyme family
regulate a broad range of cellular functions related to carcinogenesis, tumor growth, cell …

Nicotinamide adenine dinucleotide (NAD) is the core of cellular energy metabolism. NAMPT,
Sirtuins, PARP, CD38, and other molecules in this classic metabolic pathway affect many …

The emergence of PARP inhibitors as a therapeutic strategy for tumors with high genomic
instability, particularly those harboring BRCA mutations, has advanced cancer treatment …