A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Background The increased sequencing of pathogen genomes and the subsequent
availability of genome-scale functional datasets are expected to guide the experimental …

A characteristic, well-studied feature of the pathogenic protists belonging to the family
Trypanosomatidae is the compartmentalisation of the major part of the glycolytic pathway in …

Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …

In Trypanosoma cruzi, the causal agent of Chagas disease, the first seven steps of glycolysis
are compartmentalized in glycosomes, which are authentic but specialized peroxisomes …

Glycosomes are peroxisome-related organelles that have been identified in kinetoplastids
and diplonemids. The hallmark of glycosomes is their harboring of the majority of the …

The causative agent of Chagas disease, Trypanosoma cruzi, metabolizes glucose through
two major pathways: glycolysis and the pentose phosphate pathway. Glucose is taken up via …

Significance: Hexokinases are key enzymes that are responsible for the first reaction of
glycolysis, but they also moonlight other cellular processes, including mitochondrial redox …

Infection with the free-living amoeba Naegleria fowleri leads to life-threatening primary
amoebic meningoencephalitis. Efficacious treatment options for these infections are limited …