Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors in
the world. Therapeutic options for advanced HCC are limited. Systemic treatment, especially …

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is
involved in many immunological processes, including cell growth, proliferation …

Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …

Simple Summary Hepatocellular carcinoma (HCC) is the most frequent primitive cancer of
the liver, accounting for 90% of all recorded cases. HCC is the third most common cause of …

The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …

Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …

Hepatocellular carcinoma (HCC) was the third leading cause of cancer-related death
globally in 2020. The treatment of the disease is complex, with a high possibility of disease …

Splicing alterations represent an actionable cancer hallmark. Splicing factor 3B subunit 1
(SF3B1) is a crucial splicing factor that can be targeted pharmacologically (eg pladienolide …