Inositol pyrophosphates as versatile metabolic messengers
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …
metabolites whose versatile modes of action are being increasingly appreciated. These …
[HTML][HTML] Versatile signaling mechanisms of inositol pyrophosphates
MN Trung, D Furkert, D Fiedler - Current opinion in chemical biology, 2022 - Elsevier
Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which
regulate central biological processes in health and disease, such as cellular phosphate and …
regulate central biological processes in health and disease, such as cellular phosphate and …
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
Lost in condensation: poly-, cyclo-, and ultraphosphates
Conspectus Much like linear, branched, and cyclic alkanes, condensed phosphates exist as
linear, branched, and cyclic structures. Inasmuch as alkanes are the cornerstone of organic …
linear, branched, and cyclic structures. Inasmuch as alkanes are the cornerstone of organic …
Functions, Mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsP5 and InsP8 in mammalian cells
J Qi, L Shi, L Zhu, Y Chen, H Zhu, W Cheng… - Journal of …, 2024 - Springer
Water-soluble myo-inositol phosphates have long been characterized as second
messengers. The signaling properties of these compounds are determined by the number …
messengers. The signaling properties of these compounds are determined by the number …
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis
X Zhang, N Li, J Zhang, Y Zhang, X Yang, Y Luo… - Nature …, 2021 - nature.com
diphosphoinositol pentakisphosphate (5-IP7) is a signalling metabolite linked to various
cellular processes. How extracellular stimuli elicit 5-IP7 signalling remains unclear. Here we …
cellular processes. How extracellular stimuli elicit 5-IP7 signalling remains unclear. Here we …
Absolute quantitation of inositol pyrophosphates by capillary electrophoresis electrospray ionization mass spectrometry
D Qiu, VB Eisenbeis, A Saiardi… - Journal of Visualized …, 2021 - discovery.ucl.ac.uk
Inositol pyrophosphates (PP-InsPs) are an important group of intracellular signaling
molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence …
molecules. Derived from inositol phosphates (InsPs), these molecules feature the presence …
Assigning the Absolute Configuration of Inositol Poly-and Pyrophosphates by NMR Using a Single Chiral Solvating Agent
Inositol phosphates constitute a family of highly charged messenger molecules that play
diverse roles in cellular processes. The various phosphorylation patterns they exhibit give …
diverse roles in cellular processes. The various phosphorylation patterns they exhibit give …
Thiocoumarin caged nucleotides: Synthetic access and their photophysical properties
Photocages have been successfully applied in cellular signaling studies for the controlled
release of metabolites with high spatio-temporal resolution. Commonly, coumarin …
release of metabolites with high spatio-temporal resolution. Commonly, coumarin …
Intracellular delivery and deep tissue penetration of nucleoside triphosphates using photocleavable covalently bound dendritic polycations
J Ma, J Wehrle, D Frank, L Lorenzen, C Popp… - Chemical …, 2024 - pubs.rsc.org
Nucleoside triphosphates (NTPs) are essential in various biological processes. Cellular or
even organismal controlled delivery of NTPs would be highly desirable, yet in cellulo and in …
even organismal controlled delivery of NTPs would be highly desirable, yet in cellulo and in …