The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …

The apical complex is the instrument of invasion used by apicomplexan parasites, and the
conoid is a conspicuous feature of this apparatus found throughout this phylum. The conoid …

Malaria remains one of the most devastating infectious diseases. Reverse genetic screens
offer a powerful approach to identify genes and molecular processes governing malaria …

Background Artemisinin resistance is associated with delayed parasite clearance half-life in
vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both …

Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal
diseases. Their complex life cycles–often heteroxenous with sexual and asexual phases in …

Functional analysis of essential genes in the malarial parasite, Plasmodium, is hindered by
lack of efficient strategies for conditional protein regulation. We report the development of a …

Reversible protein phosphorylation regulated by kinases and phosphatases controls many
cellular processes. Although essential functions for the malaria parasite kinome have been …

P lasmodium spp. and T oxoplasma gondii are important human and veterinary pathogens.
These parasites possess an unusual double membrane structure located directly below the …