In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Abstract Background & Aims Preclinical identification of compounds at risk of causing drug
induced liver injury (DILI) remains a significant challenge in drug development, highlighting …

Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to
study using current in vitro models such as primary human hepatocyte (PHH) monolayer …

The liver is critical to consider during drug development because of its central role in the
handling of xenobiotics, a process which often leads to localized and/or downstream tissue …

Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the
development of individualized treatments has been limited by the lack of individualized …

ABSTRACT A self-organizing organoid model provides a new approach to study the
mechanism of human liver organogenesis. Previous animal models documented that …

Attrition due to nonclinical safety represents a major issue for the productivity of
pharmaceutical research and development (R&D) organizations, especially during the …

Background: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure
cases in the United States, and remains a common cause of withdrawal of drugs in both …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …