Cardiovascular diseases persist as a global health challenge that requires methodological
innovation for effective drug development. Conventional pipelines relying on animal models …

Mitochondrial dynamics homeostasis is sustained by continuous and balanced fission and
fusion, which are determinants of morphology, abundance, biogenesis and mitophagy of …

Ventricular remodeling refers to the structural and functional changes of the heart under
various stimuli or disease influences and may also be accompanied by myocardial fibrosis …

Hypertrophic cardiomyopathy and pathological cardiac hypertrophy are characterized by
mitochondrial structural and functional abnormalities. In this issue of the JCI, Zhuang et al …

Hypertrophic cardiomyopathy (HCM) is a heart condition characterized by cellular and
metabolic dysfunction, with mitochondrial dysfunction playing a crucial role. Although the …

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs) offer
versatile applications in tissue engineering and drug screening. To facilitate the monitoring …

Significance: Intestinal stem cells (ISCs) are crucial for the continuous renewal and
regeneration of the small intestinal epithelium. ISC fate decisions are strictly controlled by …

Sudden cardiac death (SCD) is defined as unexpected death due to a cardiac cause that
occurs rapidly. Despite the identification of prevention strategies, SCD remains a serious …

The poultry industry struggles with oxidative stress affecting gut health and productivity. This
study examined using 1-Deoxynojirimycin (DNJ) extracts from mulberry leaves as an …

Abstract Astragali Radix (AR) and Notoginseng Radix et Rhizoma (NR) are frequently
employed in cardiovascular disease treatment. However, the efficacy of the AR− NR …