Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells
(ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called …

Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad
range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Cancer diagnoses have been increasing worldwide, and solid tumors are among the
leading contributors to patient mortality, creating an enormous burden on the global …

Network pharmacology is an emerging interdisciplinary research method. The application of
network pharmacology to reveal the nutritional effects and mechanisms of active ingredients …

Understanding the entry of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)
into host cells is crucial in the battle against COVID-19. Using atomic force microscopy …

Interactions between carbohydrates and the proteins that bind them (lectins) are often some
of the first between a host cell and a viral invader. With its highly glycosylated spike protein …