Placenta disrupted: endocrine disrupting chemicals and pregnancy

J Gingrich, E Ticiani, A Veiga-Lopez - Trends in Endocrinology & …, 2020 - cell.com
Endocrine disrupting chemicals (EDCs) are chemicals that can interfere with normal
endocrine signals. Human exposure to EDCs is particularly concerning during vulnerable …

Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption

M Lorigo, E Cairrao - Molecular aspects of medicine, 2022 - Elsevier
Increasing evidence has associated the exposure of endocrine-disrupting chemicals (EDCs)
with the cardiovascular (CV) system. This exposure is particularly problematic in a sensitive …

Uptake, transport, and toxicity of pristine and weathered micro-and nanoplastics in human placenta cells

HM Dusza, EA Katrukha, SM Nijmeijer… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: The first evidence of micro-and nanoplastic (MNP) exposure in the human
placenta is emerging. However, the toxicokinetics and toxicity of MNPs in the placenta …

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

BI Laufer, K Neier, AE Valenzuela, DH Yasui… - Cell reports, 2022 - cell.com
Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …

[HTML][HTML] Experimental human placental models for studying uptake, transport and toxicity of micro-and nanoplastics

HM Dusza, J van Boxel, MBM van Duursen… - Science of The Total …, 2023 - Elsevier
Micro-and nanoplastics (MNPs) are ubiquitous in the environment and have recently been
found in human lungs, blood and placenta. However, data on the possible effects of MNPs …

Associations of prenatal exposure to phenols with birth outcomes

R Tang, M Chen, G Ding, X Chen, X Han, K Zhou… - Environmental …, 2013 - Elsevier
Many phenols are known to mimic or antagonize hormonal activities and may adversely
affect fetal growth. A study of 567 pregnant women was conducted to investigate the …

Drug transporters expressed in the human placenta and models for studying maternal‐fetal drug transfer

A Dallmann, XI Liu, GJ Burckart… - The Journal of Clinical …, 2019 - Wiley Online Library
Tremendous efforts have been directed to investigate the ontogeny of drug transporters in
fetuses, neonates, infants, and children based on their importance for understanding drug …

Placental transfer and metabolism: an overview of the experimental models utilizing human placental tissue

P Myllynen, K Vähäkangas - Toxicology in vitro, 2013 - Elsevier
Over the decades several ex vivo and in vitro models which utilize delivered human
placenta have been developed to study various placental functions. The use of models …

In vitro placental model optimization for nanoparticle transport studies

L Cartwright, MS Poulsen, HM Nielsen… - International journal …, 2012 - Taylor & Francis
Background Advances in biomedical nanotechnology raise hopes in patient populations but
may also raise questions regarding biodistribution and biocompatibility, especially during …

Fetal exposure to environmental chemicals; insights from placental perfusion studies

L Mathiesen, T Buerki-Thurnherr, J Pastuschek… - Placenta, 2021 - Elsevier
Introduction The burden of environmental chemicals in the human population is ubiquitous
and especially problematic in pregnancy due to potential exposure of the vulnerable fetus …