[HTML][HTML] Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats—A systematic review

K Aulehner, C Leenaars, V Buchecker… - Frontiers in Veterinary …, 2022 - frontiersin.org
Several studies suggested an informative value of behavioral and grimace scale parameters
for the detection of pain. However, the robustness and reliability of the parameters as well as …

[HTML][HTML] The neurobiology of pain and facial movements in rodents: Clinical applications and current research

A Domínguez-Oliva, D Mota-Rojas… - Frontiers in veterinary …, 2022 - frontiersin.org
One of the most controversial aspects of the use of animals in science is the production of
pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain …

Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats

AF Bedair, A Wahid, NS El-Mezayen, EA Afify - Life Sciences, 2023 - Elsevier
Aims Chronic liver disease (CLD) is a serious medical condition affecting patients globally
and pain management poses a unique challenge. ATP-sensitive potassium channels (K …

The grimace scale: a useful tool for assessing pain in laboratory animals

K Onuma, M Watanabe, N Sasaki - Experimental Animals, 2024 - jstage.jst.go.jp
Accurately and promptly assessing pain in experimental animals is extremely important to
avoid unnecessary suffering of the animals and to enhance the reproducibility of …

[HTML][HTML] Grimace scale assessment during Citrobacter rodentium inflammation and colitis development in laboratory mice

PP Peppermüller, J Gehring, E Zentrich… - Frontiers in Veterinary …, 2023 - frontiersin.org
Introduction Bacterial infections and chronic intestinal inflammations triggered by genetic
susceptibility, environment or an imbalance in the intestinal microbiome are usually long …

The neurobiology of pain and facial movements in rodents: clinical applications and current research

D Mota-Rojas, A Domínguez-Oliva… - 2022 - hekyll.services.adelaide.edu.au
One of the most controversial aspects of the use of animals in science is the production of
pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain …