Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial
cells. These transcription regulators are responsible for many important cellular processes …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

Survival of the live attenuated Bacillus Calmette-Guérin (BCG) vaccine amidst harsh host
environments is key for BCG effectiveness as it allows continuous immune response …

Nucleoid‐associated protein HU, a conserved protein across eubacteria is necessary for
maintaining the nucleoid organization and global regulation of gene expression …

Genomes of all organisms are persistently threatened by endogenous and exogenous
assaults. Bacterial mechanisms of genome maintenance must provide protection throughout …

There is increasing evidence that phenotypically drug-resistant bacteria may be important
determinants of antibiotic treatment failure. Using high-throughput imaging, we defined …

Mycobacterium tuberculosis has evolved several mechanisms to counter host defense
arsenals for its proliferation. Here we report that M. tuberculosis employs a multi-pronged …

Twelve novel substituted isatin-propylene-1H-1, 2, 3-triazole-4-methylene-moxifloxacin
hybrids 5a-l were designed, synthesized and screened for their in vitro anti-mycobacterial …

Mycobacteria are the major human pathogens with the capacity to become dormant
persisters. Mycobacterial DNA-binding protein 1 (MDP1), an abundant histone-like protein in …

Despite the tremendous improvement in overall global health heralded by the adoption of
the Millennium Declaration in the year 2000, tropical infections remain a major health …