Head and neck cancer

MD Mody, JW Rocco, SS Yom, RI Haddad, NF Saba - The Lancet, 2021 - thelancet.com
Head and neck cancer is the seventh most common type of cancer worldwide and comprise
of a diverse group of tumours affecting the upper aerodigestive tract. Although many different …

Oropharyngeal carcinoma with a special focus on HPV-related squamous cell carcinoma

RL Ferris, W Westra - Annual Review of Pathology: Mechanisms …, 2023 - annualreviews.org
Human papillomavirus–positive oropharyngeal squamous cell carcinoma (HPV-OPSCC)
has one of the most rapidly increasing incidences of any cancer in high-income countries …

Phase II randomized trial of transoral surgery and low-dose intensity modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: an ECOG …

RL Ferris, Y Flamand, GS Weinstein, S Li… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE Definitive or postoperative chemoradiation (CRT) is curative for human
papillomavirus–associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity …

[HTML][HTML] COVID-19: Global radiation oncology's targeted response for pandemic preparedness

R Simcock, TV Thomas, C Estes, AR Filippi… - Clinical and translational …, 2020 - Elsevier
As the global COVID-19 pandemic escalates there is a need within radiation oncology to
work to support our patients in the best way possible. Measures are required to reduce …

Diagnosis and management of squamous cell carcinoma of unknown primary in the head and neck: ASCO guideline

E Maghami, N Ismaila, A Alvarez… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE To provide evidence-based recommendations to practicing physicians and other
health care providers on the diagnosis and management of squamous cell carcinoma of …

Optimizing treatment de‐escalation in head and neck cancer: current and future perspectives

AJ Rosenberg, EE Vokes - The oncologist, 2021 - academic.oup.com
Abstract Treatment of locoregionally advanced head and neck squamous cell carcinoma
involves a multidisciplinary approach that combines surgery, radiotherapy, and systemic …

De-escalation after DE-ESCALATE and RTOG 1016: A Head and Neck Cancer InterGroup framework for future de-escalation studies

H Mehanna, D Rischin, SJ Wong, V Gregoire… - Journal of Clinical …, 2020 - ascopubs.org
Human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is increasing rapidly.
The younger age, significantly improved prognosis, and relative morbidity of the standard-of …

Deintensification of treatment for human papillomavirus-related oropharyngeal cancer: Current state and future directions

EO Bigelow, TY Seiwert, C Fakhry - Oral oncology, 2020 - Elsevier
Human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has
emerged as a distinct clinical entity of head and neck cancer with expected high survival …

Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a …

AC Nichols, P Lang, E Prisman, E Berthelet, E Tran… - BMC cancer, 2020 - Springer
Background Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous
cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) …

De-escalation strategies of (chemo) radiation for head-and-neck squamous cell cancers—HPV and beyond

A Rühle, AL Grosu, NH Nicolay - Cancers, 2021 - mdpi.com
Simple Summary HPV-related oropharyngeal squamous cell carcinoma patients have a very
good prognosis but are often suffering from long-term treatment-induced toxicities …