Pyroptosis, metabolism, and tumor immune microenvironment

T Du, J Gao, P Li, Y Wang, Q Qi, X Liu… - Clinical and …, 2021 - Wiley Online Library
In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Mitochondrial regulation and white adipose tissue homeostasis

Q Zhu, YA An, PE Scherer - Trends in cell biology, 2022 - cell.com
The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …

[HTML][HTML] A lipid perspective on regulated pyroptosis

Y Qiu, YN Shi, N Zhu, S Zhang, CJ Zhang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Pyroptosis is a novel pro-inflammatory cell programmed death dependent on Gasdermin
(GSMD) family-mediated membrane pore formation and subsequent cell lysis, accompanied …

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

S Qian, Y Tang, QQ Tang - Journal of Biological Chemistry, 2021 - ASBMB
Adipose tissues, including white, beige, and brown adipose tissue, have evolved to be
highly dynamic organs. Adipose tissues undergo profound changes during development …

Adipose tissue immunometabolism and apoptotic cell clearance

T Röszer - Cells, 2021 - mdpi.com
The safe removal of apoptotic debris by macrophages—often referred to as efferocytosis—is
crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging …

Emerging role of bone morphogenetic protein 4 in metabolic disorders

RK Baboota, M Blüher, U Smith - Diabetes, 2021 - Am Diabetes Assoc
Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the
TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are …

Physiological approaches targeting cellular and mitochondrial pathways underlying adipose organ senescence

P de Lange, A Lombardi, E Silvestri, F Cioffi… - International Journal of …, 2023 - mdpi.com
The adipose organ is involved in many metabolic functions, ranging from the production of
endocrine factors to the regulation of thermogenic processes. Aging is a natural process that …

Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway

X Yu, G Benitez, PT Wei, SV Krylova, Z Song… - Nature …, 2024 - nature.com
Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose
tissue (BAT) involution, a process characterized by reduction of BAT mass and function with …

Adipose cell-free DNA in diabetes

FM Humardani, LT Mulyanata, SED Putra - Clinica Chimica Acta, 2023 - Elsevier
Cancer-associated necrosis is a well-known source of cell-free DNA (cfDNA). However, the
origins of cfDNA are not strictly limited to cancer. Additionally, dietary exposure induces …

Adipocyte dysfunction promotes lung inflammation and aberrant repair: a potential target of COPD

S Zhang, X Qin, J Zhou, B He, S Shrestha… - Frontiers in …, 2023 - frontiersin.org
Background Obesity and chronic obstructive pulmonary disease (COPD) are prevailing
worldwide, bringing a heavy medical burden. Clinical and pathophysiological relationship …