The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Efforts to model the human gut microbiome in mice have led to important insights into the
mechanisms of host-microbe interactions. However, the model communities studied to date …

Summary Using untargeted metabolomics (n= 1,162 subjects), the plasma metabolite (m/z=
265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an …

The gut microbiota is implicated in immune system functions. Regulation of the metabolic
processes occurring in immune cells is crucial for the maintenance of homeostasis and …

Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A
Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and …

Recent studies show gut microbiota-dependent metabolism of dietary phenylalanine into
phenylacetic acid (PAA) is critical in phenylacetylglutamine (PAGln) production, a metabolite …

Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether
bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells …

Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Hundreds of microbiota genes are associated with host biology/disease. Unraveling the
causal contribution of a microbiota gene to host biology remains difficult because many are …