In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Renal inflammation and fibrosis are the common pathways leading to progressive chronic
kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as …

Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts
in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue …

It is generally assumed that cells interrogate the mechanical properties of their environment
by pushing and pulling on the extracellular matrix (ECM). For instance, acto-myosin …

While it has been established that a number of microenvironment components can affect the
likelihood of metastasis, the link between microenvironment and tumor cell phenotypes is …

The human CD14+ monocyte compartment is composed by two subsets based on CD16
expression. We previously reported that this compartment is perturbed in tuberculosis (TB) …

Podosomes are unique cellular entities specifically found in macrophages and involved in
cell–matrix interactions, matrix degradation, and 3D migration. They correspond to a core of …

Background The majority of microbial infections in humans are biofilm-associated and
difficult to treat, as biofilms are highly resistant to antimicrobial agents and protect …

The hematopoietic cell kinase (HCK) is a member of the SRC family of cytoplasmic tyrosine
kinases (SFKs), and is expressed in cells of the myeloid and B-lymphocyte cell lineages …