With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Dysfunction of VAMP-associated protein (VAP) is associated with neurodegeneration, both
Amyotrophic Lateral Sclerosis and Parkinson's disease. Here we summarize what is known …

A proline to serine substitution at position 56 in the gene encoding vesicle-associated
membrane protein-associated protein B (VAPB) causes some dominantly inherited familial …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the
motor system and presents with progressive muscle weakness. Most patients survive for …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …

Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a
profound loss of life quality and premature death. Around 10% of the cases are inherited and …

The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …

The fruit fly, Drosophila melanogaster, has a long and rich history as an important model
organism for biologists. In particular, study of the fruit fly has been essential to much of our …

Drosophila melanogaster has been utilized to model human brain diseases. In most of these
invertebrate transgenic models, some aspects of human disease are reproduced. Although …