The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …

The pathogenesis of pediatric inflammatory bowel disease (IBD) is only partially understood.
Strong evidence implicates a strong genetic component including high monozygotic twin …

Abstract PRDM (PRDI-BF1 and RIZ homology domain containing) family members are
sequence-specific transcriptional regulators involved in cell identity and fate determination …

MicroRNAs are known to control TLR activation in phagocytes. We have shown that
leukotriene (LT) B 4 (LTB 4) positively regulates macrophage MyD88 expression by …

Transcriptome analysis is a powerful modern tool to study possible alterations of gene
expression associated with human diseases. It turns out to be especially promising for …

Epigenetics underpins the regulation of genes known to play a key role in the adaptive and
innate immune system (AIIS). We developed a method, EpiNN, that leverages epigenetic …

Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the
prevalence of serological markers of HEV infection between different ethnic groups …

A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander,
the largest extant amphibian species. Among the 137 putative immune-related genes …

The contribution of genetic ancestry on chronic obstructive pulmonary disease (COPD)
predisposition remains unclear. To explore this relationship, we analyzed the associations …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …