A review of the molecular mechanisms of traumatic brain injury

AA Ladak, SA Enam, MT Ibrahim - World neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) refers to any insult to the brain resulting in primary (direct) and
secondary (indirect) damage to the brain parenchyma. Secondary damage is often linked to …

NLRP3 inflammasome in traumatic brain injury: Its implication in the disease pathophysiology and potential as a therapeutic target

R Chakraborty, H Tabassum, S Parvez - Life sciences, 2023 - Elsevier
Traumatic brain injury (TBI), an acquired brain injury imparted by a mechanical trauma to the
head, has significant ramifications in terms of long-term disability and cost of healthcare. TBI …

Traumatic brain injury and blood–brain barrier (BBB): underlying pathophysiological mechanisms and the influence of cigarette smoking as a premorbid condition

F Sivandzade, F Alqahtani, L Cucullo - International journal of molecular …, 2020 - mdpi.com
Traumatic brain injury (TBI) is among the most pressing global health issues and prevalent
causes of cerebrovascular and neurological disorders all over the world. In addition to the …

The dynamics of concussion: mapping pathophysiology, persistence, and recovery with causal-loop diagramming

ES Kenzie, EL Parks, ED Bigler, DW Wright… - Frontiers in …, 2018 - frontiersin.org
Despite increasing public awareness and a growing body of literature on the subject of
concussion, or mild traumatic brain injury, an urgent need still exists for reliable diagnostic …

Mechanisms involved in epileptogenesis in Alzheimer's disease and their therapeutic implications

M Altuna, G Olmedo-Saura, M Carmona-Iragui… - International journal of …, 2022 - mdpi.com
Epilepsy and Alzheimer's disease (AD) incidence increases with age. There are reciprocal
relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an …

Understanding the consequences of repetitive subconcussive head impacts in sport: brain changes and dampened motor control are seen after boxing practice

TG Di Virgilio, M Ietswaart, L Wilson… - Frontiers in human …, 2019 - frontiersin.org
Objectives The potential effects of exposure to repetitive subconcussive head impacts
through routine participation in sport are not understood. To investigate the effects of …

Neuroendocrine abnormalities following traumatic brain injury: an important contributor to neuropsychiatric sequelae

AM Molaie, J Maguire - Frontiers in endocrinology, 2018 - frontiersin.org
Neuropsychiatric symptoms following traumatic brain injury (TBI) are common and contribute
negatively to TBI outcomes by reducing overall quality of life. The development of …

Neurodegenerative pathways as targets for acquired epilepsy therapy development

PM Casillas‐Espinosa, I Ali, TJ O'Brien - Epilepsia Open, 2020 - Wiley Online Library
There is a growing body of clinical and experimental evidence that neurodegenerative
diseases and epileptogenesis after an acquired brain insult may share common etiological …

[HTML][HTML] Information transmission velocity-based dynamic hierarchical brain networks

L Jiang, F Li, Z Chen, B Zhu, C Yi, Y Li, T Zhang… - NeuroImage, 2023 - Elsevier
The brain functions as an accurate circuit that regulates information to be sequentially
propagated and processed in a hierarchical manner. However, it is still unknown how the …

Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function

X Chen, F Liu, B Li, Y Wang, L Yuan, A Yin, Q Chen… - Cell & Bioscience, 2022 - Springer
Background Neurodegenerative diseases encompass an extensive and heterogeneous
group of nervous system disorders which are characterized by progressive degeneration …