TGF-β family signaling in early vertebrate development
TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …
Molecular specification of germ layers in vertebrate embryos
C Kiecker, T Bates, E Bell - Cellular and Molecular Life Sciences, 2016 - Springer
In order to generate the tissues and organs of a multicellular organism, different cell types
have to be generated during embryonic development. The first step in this process of cellular …
have to be generated during embryonic development. The first step in this process of cellular …
Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
After fertilization, maternal factors direct development and trigger zygotic genome activation
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …
Pou5f1 transcription factor controls zygotic gene activation in vertebrates
M Leichsenring, J Maes, R Mössner, W Driever… - Science, 2013 - science.org
The development of multicellular animals is initially controlled by maternal gene products
deposited in the oocyte. During the maternal-to-zygotic transition, transcription of zygotic …
deposited in the oocyte. During the maternal-to-zygotic transition, transcription of zygotic …
Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos
Upon fertilization, the genome of animal embryos remains transcriptionally inactive until the
maternal-to-zygotic transition. At this time, the embryo takes control of its development and …
maternal-to-zygotic transition. At this time, the embryo takes control of its development and …
Pou5f3, SoxB1, and Nanog remodel chromatin on high nucleosome affinity regions at zygotic genome activation
M Veil, LY Yampolsky, B Grüning… - Genome …, 2019 - genome.cshlp.org
The zebrafish embryo is transcriptionally mostly quiescent during the first 10 cell cycles, until
the main wave of zygotic genome activation (ZGA) occurs, accompanied by fast chromatin …
the main wave of zygotic genome activation (ZGA) occurs, accompanied by fast chromatin …
Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development
C Vannier, K Mock, T Brabletz, W Driever - Journal of Biological Chemistry, 2013 - ASBMB
The ZEB1 transcription factor is best known as an inducer of epithelial-mesenchymal
transitions (EMT) in cancer metastasis, acting through transcriptional repression of CDH1 …
transitions (EMT) in cancer metastasis, acting through transcriptional repression of CDH1 …
Profiling drug-induced cell death pathways in the zebrafish lateral line
Programmed cell death (PCD) is an important process in development and disease, as it
allows the body to rid itself of unwanted or damaged cells. However, PCD pathways can …
allows the body to rid itself of unwanted or damaged cells. However, PCD pathways can …
Translational control by maternal Nanog promotes oogenesis and early embryonic development
Many maternal mRNAs are translationally repressed during oocyte development and spatio-
temporally activated during early embryogenesis, which is crucial for oocyte and early …
temporally activated during early embryogenesis, which is crucial for oocyte and early …
BMP signaling: lighting up the way for embryonic dorsoventral patterning
Y Yan, Q Wang - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
One of the most significant events during early embryonic development is the establishment
of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and …
of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and …