Hybrid azine derivatives: a useful approach for antimicrobial therapy

D Amariucai-Mantu, V Mangalagiu, I Bejan, A Aricu… - Pharmaceutics, 2022 - mdpi.com
Nowadays, infectious diseases caused by microorganisms are a major threat to human
health, mostly because of drug resistance, multi-drug resistance and extensive-drug …

Use of UV-Vis spectrometry to gain information on the mode of binding of small molecules to DNAs and RNAs

T Biver - Applied Spectroscopy Reviews, 2012 - Taylor & Francis
Ultraviolet-visible (UV-Vis) spectrometries (absorbance, linear dichroism [LD], and circular
dichroism [CD]) are relatively simple techniques that can provide important information on …

Hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity

D Mantu, V Antoci, C Moldoveanu… - Journal of enzyme …, 2016 - Taylor & Francis
The design, synthesis, structure, and in vitro anticancer and antimycobacterial activity of new
hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives are described. The …

New indolizines with phenanthroline skeleton: Synthesis, structure, antimycobacterial and anticancer evaluation

R Danac, CM Al Matarneh, S Shova, T Daniloaia… - Bioorganic & Medicinal …, 2015 - Elsevier
We report herein a feasible study concerning the design, synthesis, structure and in vitro
antimycobacterial and anticancer activity of two new classes (containing four and five fused …

Cytotoxic effects of chemotherapeutic drugs and heterocyclic compounds at application on the cells of primary culture of neuroepithelium tumors

VA Kulchitsky, VI Potkin, YS Zubenko… - Medicinal …, 2012 - ingentaconnect.com
Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93
children at removal of the brain tumors during neurosurgical operations. The individual …

Ultrasound assisted synthesis of hybrid quinoline-imidazole derivatives: a green synthetic approach

D Diaconu, D Amăriucăi-Mantu, V Mangalagiu… - RSC …, 2021 - pubs.rsc.org
A green, straightforward and efficient study for obtaining hybrid quinoline-imidazole
derivatives under ultrasound (US) irradiation as well as under conventional thermal heating …

Pyridazinic bioisosteres with potential applications in medicinal chemistry and agriculture

RA Tucaliuc, V Mangalagiu, II Mangalagiu - Processes, 2023 - mdpi.com
Bioisosteres are substituents or groups (atoms, ions, or molecules) with similar chemical or
physical properties, and which usually have similar biological properties. Pyridazine and its …

[HTML][HTML] Ultrasound assisted synthesis of imidazolium salts: An efficient way to ionic liquids

G Zbancioc, II Mangalagiu, C Moldoveanu - Ultrasonics Sonochemistry, 2015 - Elsevier
In this study a straightforward and efficient approach concerning synthesis of 1, 3-diazole
derivatives under ultrasound (US) irradiation as well as under conventional thermal heating …

Design, synthesis, and antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton

K Kuchkova, A Aricu, E Secara, A Barba, P Vlad… - Medicinal Chemistry …, 2014 - Springer
Herein we report a feasible study concerning the design, synthesis, and in vitro antimicrobial
activity of some novel homodrimane sesquiterpenoids with diazine skeleton. The reaction …

Synthesis, structure, antimycobacterial and anticancer evaluation of new pyrrolo-phenanthroline derivatives

CM Al Matarneh, II Mangalagiu, S Shova… - Journal of enzyme …, 2016 - Taylor & Francis
A study concerning design, synthesis, structure and in vitro antimycobacterial and anticancer
evaluation of new fused derivatives with pyrrolo [2, 1-c][4, 7] phenanthroline skeleton is …