Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality in
patients with neurofibromatosis type 1. In 2002, an MPNST consensus statement reviewed …

Background Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue
sarcomas. Once metastasized, prognosis is poor despite regular treatment with conventional …

Abstract “Cancer stem cells”(CSCs) can initiate tumorigenesis and metastasis and show
resistance against chemotherapy owing to the expression of prominent stem cell markers …

Malignant peripheral nerve sheath tumors (MPNST s) are an aggressive form of soft tissue
neoplasm with extremely poor prognosis and no effective medical options currently …

Objectives Pigment epithelium-derived factor (PEDF), a multifunctional endogenous
glycoprotein, has a very wide range of biological actions, notably in bone homeostasis. The …

Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). PEDF
(Pigmented Epithelium Derived Factor) is an anti-angiogenic, neurotrophic and self-renewal …

This study aimed to explore the potential therapeutic effects of the combination of pigment
epithelium-derived factor (PEDF) and radiation on lung cancer. The Lewis lung cancer (LLC) …

In this chapter, we aim to discuss the current available in vitro or in vivo models of peripheral
nerve sheath tumors (PNSTs). The in vitro models are composed of two-dimensional cell …

Objective Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas
characterized by high recurrence rates and early metastases. These tumors arise more …