Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in
the pathogenesis of heart failure (HF). However, the specific molecular causes underlying …

In heart failure (HF), arrhythmogenic spontaneous sarcoplasmic reticulum (SR) Ca2+
release and afterdepolarizations in cardiac myocytes have been linked to abnormally high …

MicroRNAs (miRNAs) belong to the family of small non-coding RNAs that mediate gene
expression by post-transcriptional regulation. Increasing evidence have demonstrated that …

Dilated cardiomyopathy (DCM) is a frequent cause of cardiac disability, congestive heart
failure (CHF), and arrhythmic death in dogs. The etiology of DCM is usually …

Sarcolipin (SLN) is a small molecular weight sarcoplasmic reticulum (SR) membrane protein
expressed both in cardiac and skeletal muscle tissues. Recent studies using transgenic …

Kinase/phosphatase balance governs cardiac excitability in health and disease. Although
detailed mechanisms for cardiac kinase regulation are established, far less is known …

In this study, we investigated the role of elevated sarcoplasmic reticulum (SR) Ca 2+ leak
through ryanodine receptors (RyR2s) in heart failure (HF)-related abnormalities of …

Background—Cardiac dyssynchrony in the failing heart worsens global function and
efficiency and generates regional loading disparities that may exacerbate stress-response …

The role of IKCa in cardiac repolarization remains controversial and varies across species.
The relevance of the current as a therapeutic target is therefore undefined. We examined the …

Aims We sought to define the underlying mechanisms for atrial fibrillation (AF) during
chronic heart failure (HF). Methods and results Preliminary studies showed that 4 months of …