The role of dendritic cell subsets and innate immunity in the pathogenesis of type 1 diabetes and other autoimmune diseases

JD Price, KV Tarbell - Frontiers in immunology, 2015 - frontiersin.org
Dendritic cells (DCs) are key antigen-presenting cells that have an important role in
autoimmune pathogenesis. DCs control both steady-state T cell tolerance and activation of …

Cellular immunotherapy in mice prevents maternal hypertension and restores anti-inflammatory cytokine balance in maternal and fetal tissues

G Gray, DG Scroggins, KT Wilson… - International journal of …, 2023 - mdpi.com
Preeclampsia is the leading cause of maternal–fetal morbidity worldwide. The concept that
persistent feto-placental intolerance is important in the pathogenesis of preeclampsia (PreE) …

Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation

T Hahn, J Wang, LM Preus, E Karaesmen, A Rizvi… - …, 2021 - thelancet.com
Background Identification of non-human leukocyte antigen (HLA) genetic risk factors could
improve survival after allogeneic blood or marrow transplant (BMT) through matching at …

CXCR4 blockade reduces the severity of murine heart allograft rejection by plasmacytoid dendritic cell-mediated immune regulation

J Fu, CHK Lehmann, X Wang, M Wahlbuhl… - Scientific Reports, 2021 - nature.com
Allograft-specific regulatory T cells (Treg cells) are crucial for long-term graft acceptance
after transplantation. Although adoptive Treg cell transfer has been proposed, major …

Murine precursors to type 1 conventional dendritic cells induce tumor cytotoxicity and exhibit activated PD-1/PD-L1 pathway

MS Molina, EA Hoffman, J Stokes, N Kummet… - Plos one, 2022 - journals.plos.org
The immediate precursor to murine type 1 conventional DCs (cDC1s) has recently been
established and named “pre-cDC1s”. Mature CD8α+ cDC1s are recognized for suppressing …

Bendamustine conditioning skews murine host DCs toward pre-cDC1s and reduces GvHD independently of Batf3

MS Molina, J Stokes, EA Hoffman, J Eremija… - Frontiers in …, 2020 - frontiersin.org
Graft-versus-host disease (GvHD) remains the second leading cause of death in allogeneic
hematopoietic stem cell transplantation recipients, highlighting the need for improved …

Generation of Human Regulatory Dendritic Cells from Cryopreserved Healthy Donor Cells and Hematopoietic Stem Cell Transplant Recipients

SM Scroggins, AJ Schlueter - Cells, 2023 - mdpi.com
Acute graft versus host disease (GVHD) remains a significant complication following
hematopoietic stem cell transplant (HSCT), despite improved human leukocyte antigen …

[HTML][HTML] Impact of HBeAg on the maturation and function of dendritic cells

S Lan, L Wu, X Wang, J Wu, X Lin, W Wu… - International Journal of …, 2016 - Elsevier
Objectives HBV infection typically leads to chronic hepatitis in newborns and some adults
with weakened immune systems. The mechanisms by which virus escapes immunity remain …

[PDF][PDF] 核苷(酸) 类药物治疗慢性乙型肝炎患者影响HBeAg 血清转换的免疫学因素研究进展

曹辉, 张玮 - 实用肝脏病杂志, 2018 - manu43.magtech.com.cn
宿主的免疫系统功能决定了乙型肝炎病毒(HBV) 感染的最终转归. 核苷(酸) 类药物抗病毒治疗能
快速降低病毒载量, 恢复宿主的免疫功能, HBeAg 血清转换就是宿主免疫系统功能部分恢复的 …

Monotherapy with anti-CD70 antibody causes long-term mouse cardiac allograft acceptance with induction of tolerogenic dendritic cells

J Zhao, W Que, X Du, M Fujino, N Ichimaru… - Frontiers in …, 2021 - frontiersin.org
Allograft rejection has been an obstacle for the long-term survival of patients. CD70, a tumor
necrosis factor (TNF) family member critically expressed on antigen-presenting cells and …