High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

Background and Aims Non-alcoholic steatohepatitis (NASH)-related hepatocellular
carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We …

Background Cancer incidence is higher in men than in women at most shared anatomic
sites for currently unknown reasons. The authors quantified the extent to which behaviors …

Background Accumulated evidence supports the existence of sex-associated differences in
immune systems. Understanding the role of sex in immune-related adverse events (irAEs) is …

Sex and gender disparities in bladder cancer have long been a subject of interest to the
cancer research community, wherein men have a 4 times higher incidence rate than women …

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours
respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly …

Genetic networks are characterized by extensive buffering. During tumor evolution,
disruption of functional redundancies can create de novo vulnerabilities that are specific to …

Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …