Background Benzodiazepine misuse is a growing public health problem, with increases in
benzodiazepine-related overdose deaths and emergency room visits in recent years …

Treatment of Benzodiazepine Dependence | New England Journal of Medicine Skip to main
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This paper reviews studies examining the pharmacological interactions and epidemiology of
the combined use of opioids and benzodiazepines (BZDs). A search of English language …

Benzodiazepine (BZD) abuse has reached epidemic levels and results in poor outcomes,
particularly when combined with concomitant central nervous system depressants. BZDs are …

Drug interactions are a leading cause of morbidity and mortality. Methadone and
buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients …

Despite proven clinical utility, buprenorphine has not been used widely for the treatment of
chronic pain. Questions about “ceiling effect” or bell-shaped curve observed for analgesia in …

The British Association for Psychopharmacology guidelines for the treatment of substance
abuse, harmful use, addiction and comorbidity with psychiatric disorders primarily focus on …

Buprenorphine has been used internationally for the treatment of opioid use disorder (OUD)
since the 1990s and has been available in the United States for more than a decade. Initial …

Buprenorphine is an opioid that has a complex and unique pharmacology which provides
some advantages over other potent mu agonists. We review 12 reasons for considering …

Buprenorphine/naloxone (Suboxone®) comprises the partial μ-opioid receptor agonist
buprenorphine in combination with the opioid antagonist naloxone in a 4: 1 ratio. When …