Drug resistance in human cancers—Mechanisms and implications

S Vijayakumar, R Dhakshanamoorthy, A Baskaran… - Life Sciences, 2024 - Elsevier
Cancers have complex etiology and pose a significant impact from the health care
perspective apart from the socio-economic implications. The enormity of challenge posed by …

A safety review of recently approved and emerging drugs for patients with relapsed or refractory multiple myeloma

S Midha, MA Hartley-Brown, CC Mo… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Multiple new drugs have been approved over the past 5 years for the treatment
of relapsed/refractory multiple myeloma (RRMM), and these are being increasingly widely …

Upregulated expression of Erbb2/Her2 in multiple myeloma as a Predictor of poor survival outcomes

FM Uckun, S Qazi - International Journal of Molecular Sciences, 2023 - mdpi.com
The main goal of the present study was to examine if the RNA-sequencing (RNAseq)-based
ERBB2/HER2 expression level in malignant plasma cells from multiple myeloma (MM) …

How artificial intelligence revolutionizes the world of multiple myeloma

M Romero, A Mosquera Orgueira… - Frontiers in …, 2024 - frontiersin.org
Multiple myeloma is the second most frequent hematologic malignancy worldwide with high
morbidity and mortality. Although it is considered an incurable disease, the enhanced …

From spear to trident: upgrading arsenal of CAR-T cells in the treatment of multiple myeloma.

J Zhao, M Zheng, L Ma, T Guan, L Su - Heliyon, 2024 - cell.com
Multiple myeloma (MM), marked by abnormal proliferation of plasma cells and production of
monoclonal immunoglobulin heavy or light chains in the majority of patients, has traditionally …

Current Strategies and Future Directions in Multiple Myeloma: Disease Overview and Pathophysiology, Conventional Treatments and Emerging Therapies …

NA Kerna, KD Pruitt, NDV Carsrud, DC Ngwu… - European Journal of …, 2024 - ejmhr.com
The review examines multiple myeloma, including pathophysiology, conventional
treatments, current management strategies, treatment challenges, and emerging therapies …

[PDF][PDF] Role of Cytogenetics in Multiple Myeloma: Advancing Diagno-sis, Prognosis, and Treatment

Y Zhang, Y Wang - 2023 - wecmelive.com
Multiple Myeloma (MM), a prevalent hematological cancer, remains a challenge due to its
intricate nature and variable outcomes. Cytogenetics, the study of chromosome structure …

Progression-free survival as a surrogate endpoint for overall survival in patients with relapsed or refractory multiple myeloma

M Dimopoulos, P Sonneveld, S Manier, A Lam… - BMC cancer, 2024 - Springer
Objectives The goal of the research was to assess the quantitative relationship between
median progression-free survival (PFS) and median overall survival (OS) specifically among …