Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

Despite its abundance in the environment, iron is poorly bioavailable and subject to strict
conservation and internal recycling by most organisms. In vertebrates, the stability of iron …

During pregnancy, iron needs to increase substantially to support fetoplacental development
and maternal adaptation to pregnancy. To meet these iron requirements, both dietary iron …

The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our
understanding of iron disorders, and its measurement should advance diagnosis/treatment …

Hypoxia-inducible factor–prolyl hydroxylase domain inhibitors (HIF-PHIs) are a promising
new class of orally administered drugs currently in late-stage global clinical development for …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Anemia is a common feature of CKD associated with poor outcomes. The current
management of patients with anemia in CKD is controversial, with recent clinical trials …

Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the
plasma iron concentrations in humans remain stable at 10–30μM. While most of the iron …

Disruptions in iron homeostasis from both iron deficiency and overload account for some of
the most common human diseases. Iron metabolism is balanced by two regulatory systems …

Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …