The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …

Highlights•Improvements in all-atom simulations and implicit solvent models now allow IDP
simulations with realistic dimensions to be performed.•Native-centric coarse-grained …

Highlights•Intrinsically disordered proteins mostly function by molecular recognition.•Post-
translational modifications regulate the interactions of IDPs.•Structural disorder can facilitate …

Highlights•Classically, allostery induces a functional switch through a conformational
change.•Lately numerous studies concluded that allostery takes place through …

Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

Intrinsically disordered proteins (IDPs) are characterized by a lack of persistent structure.
Since their identification more than a decade ago, many questions regarding their functional …

Allosteric regulatory processes are implicated at all levels of biological function. Recent
advances in our understanding of the diverse and functionally significant class of intrinsically …

Intrinsically disordered proteins often become structured upon interacting with their partners.
The mechanism of this 'folding upon binding'process, however, has not been fully …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Mediator, an important component of eukaryotic transcriptional machinery, is a huge
multisubunit complex. Though the complex is known to be conserved across all the …