Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

Background Mutations in the tumor-suppressor gene VHL cause oversecretion of vascular
endothelial growth factor by clear-cell renal carcinomas. We conducted a clinical trial to …

The ability of tumours to induce new blood-vessel formation has been a major focus of
cancer research over the past few decades, and vascular endothelial growth factor (VEGF) …

In the last ten years, we have made considerable progress in our genetic and molecular
understanding of all aspects of skeletal development, chondrogenesis, joint formation, and …

The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …

Evidence accumulating over the last decade has established the fundamental role of
vascular endothelial growth factor (VEGF) as a key regulator of normal and abnormal …