Classical amination methods involve the reaction of a nitrogen nucleophile with an
electrophilic carbon center; however, in recent years, umpoled strategies have gained …

1, 3-Diamines not only are significant motifs in natural products, but also serve as building
blocks in synthetic organic chemistry. However, unlike their 1, 2-diamine counterparts …

Asymmetric organocatalysis has proven to be one of the most versatile methods for the
enantioselective α-functionalisation of aldehydes. Initially pioneered by the report of an L …

Summary Chiral 1, 3-propanediamine moieties are present in a range of bioactive small
molecules, chiral catalysts, and ligands. The enantioselective desymmetrization of 2 …

Imines are among the most ubiquitous species in organic and bioorganic chemistry;
however, the reactivities of N-alkyl unsaturated imines have not been thoroughly explored …

A simple and highly efficient approach to hydroxylated pyrrolizidine and indolizidine is
developed from an aldehyde as a starting material using organocatalytic and asymmetric …

A general organocatalytic method has been developed for the asymmetric synthesis of α-
hydrazino-γ-fluoro alcohols, a precursor to syn/anti-1, 3-fluoro amines. The strategy employs …

The direct α-amination of carbonyl compounds using organocatalysts represents a powerful
and atom-economical tool for asymmetric C–N bond formation. We describe a complete …

Room temperature E1cB N–N cleavage of oxazolidinone hydrazides via N-alkylation with
diethyl bromomalonate and potassium or caesium carbonate as base in acetonitrile is …

A very efficient route to the diastereoselective synthesis of polyhydroxy pyrrolidines,
piperidines and azepanes from an aldehyde derivative of ribose is reported. Asymmetric α …