Purpose Apoptosis is an important physiological process, making a great difference to
development and tissue homeostasis. Osteoarthritis (OA) is a chronic joint disease …

Despite the development of standard therapies, including surgery, radiotherapy and
chemotherapy, survival rates for head and neck squamous cell carcinoma (HNSCC) have …

Notch signaling is a well-known key player in the communication between adjacent cells
during organ development, when it controls several processes involved in cell …

Glioma is the most aggressive primary brain tumor and is notorious for resistance to
chemoradiotherapy. Although its associated mechanisms are still not completely …

Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, to
the interactions of malignant plasma cells with the bone marrow (BM) microenvironment …

Colorectal cancer is the third most diagnosed cancer worldwide and linked to
dietary/lifestyle factors. Arthrospira (Spirulina) platensis (AP) contains bioactive compounds …

Glioma stem cells (GSCs) have been proven to be resistant to various therapeutic strategies,
such as temozolomide chemotherapy and radiotherapy, leading to glioma recurrence …

Background The Notch signaling pathway has been reported to play a pivotal role in
tumorigenesis. Emerging evidence has demonstrated that the Notch signaling pathway …

Internal tandem duplication (ITD) mutations of FMS-like tyrosine kinase-3 (FLT3) are the
most frequent genetic alterations in acute myeloid leukemia (AML) and predict a poor …

Notch signaling plays an important role in several cellular functions including growth,
differentiation, cell fate determination and stemness. Increased Notch activity has been …