The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

AMP-activated protein kinase (AMPK) is an energy sensor activated by increases in [AMP] or
by oxidant stress (reactive oxygen species [ROS]). Hypoxia increases cellular ROS …

Ca2+ signals control cell migration by regulating forward movement and cell adhesion.
However, it is not well understood how Ca2+-regulatory proteins and second messengers …

Although autophagy is critical for pancreatic β-cell function, the role and mechanism of
mitophagy in β-cells are unclear. We studied the role of lysosomal Ca2+ in TFEB activation …

Elevation of cytosolic Ca2+ levels through the activation of store-operated Ca2+ release-
activated Ca2+ (CRAC) channels is involved in mediating a disparate array of cellular …

Canonical transient receptor potential (TRPC) channels control influxes of Ca2+ and other
cations that induce diverse cellular processes upon stimulation of plasma membrane …

Introduction: The beneficial effects of oleic acid in cancer processes can no longer be
doubted, but little is known about the mechanisms of action behind this phenomenon. Aim …

Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal
pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure …

Chronic neurohormonal and mechanical stresses are central features of heart disease.
Increasing evidence supports a role for the transient receptor potential canonical channels …